Download Biology of IGF-1: Its Interaction with Insulin in Health and by Jamie Goode PDF

By Jamie Goode

Show description

Read Online or Download Biology of IGF-1: Its Interaction with Insulin in Health and Malignant States (Novartis Foundation Symposia) PDF

Similar endocrinology & metabolism books

Primary Hyperlipidemias: An Atlas Of Investigation And Diagnosis

Drawing upon a wealthy number of visible fabric, this ground-breaking ebook illustrates the total diversity of lipid issues and explores the various different types of either fundamental and secondary dyslipoproteinemias. via concerning the masses of top quality photographs incorporated during this paintings, physicians may be in a position to expectantly establish and diagnose the full diversity of lipid problems.

Facilitative Glucose Transporters in Articular Chondrocytes: Expression, Distribution and Functional Regulation of GLUT Isoforms by Hypoxia, Hypoxia Mimetics

Articular cartilage is a distinct and hugely really expert avascular connective tissue during which the provision of oxygen and glucose is considerably less than synovial fluid and plasma. Glucose is a necessary resource of strength in the course of embryonic progress and fetal improvement and is essential for mesenchymal mobile differentiation, chondrogenesis and skeletal morphogenesis.

International Textbook of Obesity

The superiority of weight problems has now reached such proportions that during many elements of the realm it really is essentially the most dominant illnesses. weight problems results in a few severe illnesses reminiscent of kind 2 diabetes, heart problems, high blood pressure, stroke and melanoma in addition to mental difficulties and a terrible caliber of lifestyles.

Endocrine Disruptors 2011

Endocrine Disruptors 2011 is a day symposium organised through iSmithers, and sister businesses Springborn Smithers and Smithers Viscient, aimed toward addressing key issues regarding the assessment of inauspicious results at the endocrine process and corresponding regulatory necessities. The convention will collect specialists from academia, govt, and from all over the world to target present and destiny tendencies in checking out, interpretation and overview of try out effects and the way this pertains to or affects regulatory actions.

Extra info for Biology of IGF-1: Its Interaction with Insulin in Health and Malignant States (Novartis Foundation Symposia)

Example text

There is always the cleavage outside the circulation, and some of this is washing back. Then you get alterations in the clipping that is actually occurring in pathologies. LÖnning: To play the devil’s advocate, we know that the vessels in the tumour tissue have a di¡erent fenestration compared to normal vessels. Could what you see be due to higher leakage of clipped proteins, which are being clipped in the tumour tissue? Holly: We can do a number of di¡erent assays on the serum samples from these patients and show that there is increased activity in the circulation.

Laron: I read somewhere that there is increased production of prolactin in prostate cancer. Pollak: There are a lot of papers out about prolactin receptors on prostate cancer tissue. It is not my work and I am not prepared to defend it, but I am interested that for at least a decade papers have been published showing prolactin receptors, GHRH and other hypothalamic or pituitary receptors present on neoplastic tissue. The relevance of these observations has never really been established. LeRoith: I can comment on one of them.

Insulin signalling propagates through three major pathways: the PI3K, the MAP kinase, and the Cbl/CAP pathways (Fig. 2). While these pathways share several signalling elements that intricately a¡ect one another, each of these pathways has some unique characteristics. The MAPK pathway can be considered as a general signalling pathway which is activated by a number of growth factor receptors including insulin, all leading to enhanced cell growth, while the PI3K and the Cbl/CAP pathways, triggered by insulin, generate biological responses that are more unique to insulin action.

Download PDF sample

Rated 4.18 of 5 – based on 16 votes