By Gregory Pincus and Erwin P. Vollmer (Eds.)
Read or Download Biological Activities of Steroids in Relation to Cancer. Proceedings of a Conference Sponsored by the Cancer Chemotherapy National Service Center, National Cancer Institute, National Institutes of Health, U. S. Department of Health, Education and Welfare PDF
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Additional resources for Biological Activities of Steroids in Relation to Cancer. Proceedings of a Conference Sponsored by the Cancer Chemotherapy National Service Center, National Cancer Institute, National Institutes of Health, U. S. Department of Health, Education and Welfare
There is no evidence that prostatic cancer in man is caused by testosterone. First, prostatic cancer usually develops at an age when testicular function is declining, as measured by urinary bioassay and determination of 17-ketosteroid excretion. A survey of patients over 45 who had received intensive androgen therapy for noncancerous reasons did not demonstrate an increased incidence of prostatic cancer (68). Testosterone has also been administered in high doses for 3 months to patients with advanced prostatic cancer by Brendler et al.
Compound I itself is completely nonandrogenic. Compound II is only slightly androgenic, but compound III is about one-fifth as androgenic as androsterone. B e sides, all three compounds are antiestrogenic, as tested by vaginal smear and uterine weight methods. The compounds in question are estran-l7ß-ol-3-one: 5α,10α; 5β,10β; and 5α,10β isomers. Η . J. R i n g o l d : We published recently the synthesis of a series of 19-nordihydroallotestosterone derivatives prepared by lithium ammonia reduction of the corresponding 4 Δ - 3 - k e t o n e s .
The studies of Huggins and co-workers extended this relationship considerably, demonstrating in the dog that (1) castration caused complete cessation of prostatic secretion; (2) testosterone propionate in the castrate dog increased prostatic size and secretion; (3) estrogen decreased prostatic size and secretion; (4) estrogen administration with androgen decreased or abolished prostatic secretion, and prostatic size decreased. The above results then led Huggins and co-workers and others to employ estrogens and castration clinically.