By Richard J. Glassock (auth.), Claudio Ponticelli, Luigi Minetti, Giuseppo D’Amico (eds.)
RICHARD J. GLASSOCK Introducing a systematic symposium is an doubtful and hard job. The comments mustn't ever be too particular lest the participant's later contributions be intruded upon, but an summary of the pursuits and ambitions of the convention might be provided in an inquisitive and stimulating style. might be a compromise place will be to make a couple of common statements and pose a restricted variety of questions which optimistically might then be addressed dur ing the formal or casual parts of the assembly. A end incorpo of the relevance of the explicit subject to the extra score a few views worldwide problems with illness and its effects should be acceptable. The ambitions and targets of this convention, as set forth via its organizers, Professors Ponti celli, D'Amico and Minetti, are really basic and directly ahead; specifically, to study and elucidate the immunopathophysiology of cryoimmunoglobulins and auto-antibodies to immunoglobulins (lg) and, secondarily, to discover the prospective participation of those disordered states in glomerular damage. As such, this convention is mainly dedicated to an research of 2 homes of convinced species of the globulin fraction of serum proteins, in particular the facility to self affiliate at the foundation of immune interactions and to shape insoluble aggregates while uncovered to diminished ambient temperature. As we will see, those houses are usually dis tinctly related.
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Additional info for Antiglobulins, cryoglobulins and glomerulonephritis: Second International Milano Meeting of Nephrology 30 September – 1 October 1985
25 Acknowledgement Funding for this research supported in part by grants AM25443, AG04100, AM07144, and RR00833 from the National Institutes of Health. SF is the recipient of a Research Career Development Award (AG00279) from the National Institutes of Health. PC is an Investigator of the Arthritis Foundation. This is publication number 4226BCR from the Research Institute of Scripps Clinic. References 1. Waaler E: On the occurrence of a factor in human serum activating the specific agglutination of sheep blood corpuscles.
J Exp Med 158: 529-545, 1983. 14. Coulie P, Van Snick J: Rheumatoid factors and secondary immune responses in the mouse. II. Incidence, kinetics and induction mechanisms. Eur J Immunol 13: 895-899, 1983. 15. Welch MJ, Fong S, Vaughan JH, Carson DA: Increased frequency of rheumatoid factor precursor B lymphocytes after immunization ofnorrnal adults with tetanus toxoid. Clin Exp Immunol 51: 299-305, 1983. 26 16. Hayakawa K, Hardy RR, Parks DR, Herzenberg LA: The 'Ly-l B' subpopulation in normal, immunodefective, and autoimmune mice.
Kabat E, Wu T, Bilofsky H, Reid-Miller M, Perry H: Sequences of proteins of immunologic interest. S. Dept. of Health and Human Services, Washington, DC, 1983. 29 3. Regulatory Idiotopes and Diseases CONSTANTIN A. BONA Idiotypes are phenotypic markers of V region genes encoding the specificity of two polypeptide chains which constitute the antigen receptor of T or B lymphocytes. Two categories of idiotopes are expressed on the immune receptor oflymphocytes. Individual idiotypes are clonotypic antigenic determinants expressed only by a single clone.