By Terry F. Davies
In A Case-Based Guide to Clinical Endocrinology, Second version, a popular workforce of unusual clinicians once back offers stimulating instruction and insights into a large choice of endocrine topics, teaching readers modern administration of the stipulations defined and offering designated access into the literature. Importantly, a few of the very important parts within the present curriculum for scientific endocrine education as instructed by way of the organization of software administrators in scientific Endocrinology, Diabetes and Metabolism are coated during this textual content. completely up-to-date, this new version not just covers new remedy techniques but additionally emphasizes the most recent investigative advances in either imaging and molecular diagnostics. to enhance studying and retention of information, a question-based method is utilized in some of the case experiences. scholars, citizens, fellows, and practitioners will locate this connection with be a good method to overview their understanding and elevate their skills and abilities in sufferer research and administration. a useful contribution to the sector, A Case-Based Guide to Clinical Endocrinology, Second Edition, bargains an identical comprehensive volume of thought-provoking case-studies that made the 1st variation of vital significance to all clinicians who deal with sufferers with endocrine disorders.
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Extra resources for A Case-Based Guide to Clinical Endocrinology
2 Acromegaly, Awareness Is Paramount for Early Diagnosis… 17 Fig. 1 Contrast-enhanced T1-weighted coronal and sagittal MR images; preoperative and 3 months postoperative Why Does Acromegaly Fail to Be Diagnosed for Years? Growth hormone (GH) is the most abundant of the pituitary hormones and GH secretory cells (somatotrophs) make up to 50 % of total anterior pituitary cells. GH hypersecretion is usually the result of somatotroph adenomas. Ectopic GH or GH-releasing hormone (GHrH) hypersecretion is very rare.
Biochemical evaluation revealed significantly elevated IGF-1 levels. The following are correct about IGF-1 levels in acromegaly, except: (A) Will not decrease in response to pegvisomant treatment because the drug blocks only growth hormone receptors (B) IGF1 levels correlate with disease severity (C) It is important to adjust IGF1 levels for age and sex (D) Will normalize with successful treatment 3. A 38-year-old male is receiving a growth hormone receptor antagonist, pegvisomant, after unsuccessful treatment with surgery, radiation, and somatostatin receptor ligands.
Her liver panel normalized after stopping ketoconazole. G. Yedinak et al. Fig. 2 Case study patient evaluation and treatment timeline; mean urine free cortisol (μg/24 h) vs. time (months) The addition of cabergoline was attempted, however, the patient did not tolerate the drug even at lower doses and experienced profound nausea and dizziness; cabergoline was stopped in less than a month. Alternative medical agents were eventually considered. Mifepristone (Korlym), a steroid that binds competitively to glucocorticoid and progesterone receptors, blocks the action of cortisol at the level of the cortisol receptor and has been approved by the US Federal Drug Administration (FDA) for treatment of CS associated with hyperglycemia.